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TB-500 has been through Phase I and Phase II clinical trials of intravenous thymosin beta-4 with no serious adverse events reported in the published cohorts

This non-linear dose-response is characteristic of peptides that operate through receptor saturation rather than systemic hormonal signalling

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28-30 Furthermore, the inflammatory state induced by atherosclerosis increases plaque vulnerability to destabilization and rupturean event that triggers pronounced pro-coagulation processes